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Child brain tumour research projects

Current high grade brain tumour research projects

Here are the research projects we are currently funding that relate to understanding or treating high grade brain tumours in children

Dr Darren Hargrave

Tumour-targeted drugs for kids with diffuse midline glioma (aka DIPG)

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Dr Darren Hargrave

Tumour-targeted drugs for kids with diffuse midline glioma (aka DIPG)

We’re funding the UK participation of BIOMEDE, an international, adaptive clinical trial for children with Diffuse Midline Gliomas - pontine location (DMG, formerly known as DIPG). The trial is the first of its kind because it requires the children to have a biopsy of the tumour, and based on the molecular traits of the tumour different treatments are assigned.

The adaptive nature of this trial means that as new treatments become available for this kind of tumour, they can be added into the trial. This is key so that children get access to the new, potentially life-saving treatments faster.

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Dr Adrian Bracken

Finding new methods to treat Diffuse Midline Glioma

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Dr Adrian Bracken

Finding new methods to treat Diffuse Midline Glioma

Dr Adrian Bracken and his research team at Trinity College Dublin aim to develop new methods to treat diffuse midline glioma, formerly known as Diffuse Intrinsic Pontine Glioma (DIPG).

Previous research has demonstrated that the regulation of chromatin is disrupted in various cancers. Chromatin regulation refers to the process of DNA being wrapped around special proteins called histones. The research team will be focusing on finding new ways to block the activity of a particular protein involved in chromatin deregulation.

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Prof. Steve Clifford

INSTINCT:on a mission to beat childhood brain tumours

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Professor Steve Clifford

INSTINCT:on a mission to beat childhood brain tumours

Our INSTINCT programme brings together experts from Newcastle University, the Institute of Cancer Research (ICR) and the UCL Institute for Child Health in London to research high-risk childhood brain tumours, including DIPG.

The research programme on DIPG is being led by Dr Chris Jones at the Institute of Cancer Research. Dr Jones has extensive experience in understanding the genetic basis of these tumours and what is driving tumour growth and then developing new drugs that target the genes involved. 

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Prof. Colin Watts

Tessa Jowell BRAIN MATRIX

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Professor Colin Watts

Tessa Jowell BRAIN MATRIX

The Tessa Jowell BRAIN-MATRIX is a first-of-its-kind clinical trial that will enable doctors to treat brain tumours with drugs that are more targeted than ever before. We are excited to be investing £2.8 million to set the trial up, and to drive it into the future.

Although the trial is being led from the UK, we expect it to deliver global impact for brain cancer patients.

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Prof. Colin Kennedy

The PROMOTE Study

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Professor Colin Kennedy

The PROMOTE Study

The project is named The PROMOTE Study - Patient Reported Outcome Measures Online To Enhance Communication and Quality of Life after childhood brain tumour.

The PROMOTE team are developing an online programme called KLIK which will be used by children and their families to keep track of any issues they have between consultations.

This research will propel our ability to understand, and potentially prevent, the harsh side effects of brain tumour treatment in children to help accelerate a change for those affected.

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Dr Paul Northcott

Medulloblastoma Epigenome Regulation in Treatment (MERIT)

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Dr Paul Northcott

Medulloblastoma Epigenome Regulation in Treatment (MERIT)

Previous research has shown that epigenetic changes contribute to treatment resistance in medulloblastomas. Epigenetic changes refer to changes in the structure of DNA that alter the way DNA is 'read' by the cell. The aim of this research programme, led by Dr Paul Northcott, is to identify the epigenetic changes occurring in Group 3 medulloblastomas in response to treatment.

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Prof. Terrance Johns

Preventing resistance to targeted therapies

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Professor Terrance Johns

Preventing resistance to targeted therapies

Despite aggressive treatment with surgery, radiotherapy and chemotherapy, patients with HGGs have an extremely poor prognosis.

A number of targeted therapies have also been tested but have failed to improve outcomes for these patients, highlighting the urgent need to better understand the biology of these tumours and why treatments fail.

This research aims to identify new drug combinations that are more effective and may improve survival for patients with HGGs. And by using treatments that are already approved and used in clinical practice, this process will be dramatically sped up.

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Dr Laure Bihannic

Understanding the origins of medulloblastoma

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Dr Laure Bihannic

Understanding the origins of medulloblastoma

To create effective preclinical tumour models, it is imperative to know the cells from which the tumours originate. While it is known which cells WNT and SHH medulloblastomas arise from, the cellular origins of Groups 3 and 4 remain unknown. The aim of this research project, led by Dr Laure Bihannic, is to understand which cells give rise to Groups 3 and 4 medulloblastomas and use this knowledge to create accurate preclinical models for these subgroups.

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Dr Ruman Rahman

'Shining light' on childhood brain tumours to reveal new therapy targets

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Dr Ruman Rahman

'Shining light' on childhood brain tumours to reveal new therapy targets

Identifying unique alterations in the genetic make-up of ependymoma is beginning to provide clues for new targeted treatments. One such key alteration is a mutation called C11orf95-RELA, which is formed as two genes fuses together.

Dr Rahman at The University of Nottingham will use a powerful gene editing tool to allow his team to control the genetic pathways involved in the fusion of C11orf95-RELA.

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Prof. Steve Clifford

PNET5 trial: transforming treatments for childhood brain tumours

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Professor Steve Clifford

PNET5 trial: transforming treatments for childhood brain tumours

Medulloblastomas are the most common high grade brain tumours in children. The standard treatment for this tumour type is removing the tumour with surgery, followed with chemotherapy and radiotherapy.

However, these treatments are quite aggressive and cause long-term, life-altering disabilities. The PNET5 clinical trial aims to improve the quality of survival of these children by providing kinder and tailored treatments.

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Prof. Chris Clark

Taking a closer look at brain injury

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Professor Chris Clark

Taking a closer look at brain injury

Treatment for children with medulloblastoma, an aggressive type of brain tumour, is frequently accompanied by damage to the brain with long-term implications such as memory loss.

His research focus is on the development and application of imaging for the understanding of neurological disability. The development of these methods will lead to better neurosurgical planning in both children and adults.

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Dr Paul Northcott

Understanding the significance of medulloblastoma subtypes

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Dr Paul Northcott

Understanding the significance of medulloblastoma subtypes

The 2016 revision of brain tumour classifications from the World Health Organisation (WHO) included the four consensus subgroups for medulloblastoma (WNT-activated, SHH-activated, Group 3 and Group 4).

To date, medulloblastomas in Groups 3 and 4 have been notoriously difficult to treat because they have many different and unpredictable responses to treatment.

Dr Northcott’s team will use sophisticated statistical analysis, on over 1,200 samples, to determine if there are further subtypes within these subgroups.

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Prof. Louis Chesler

New drug development for medulloblastoma

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Professor Louis Chesler

New drug development for medulloblastoma

Professor Chesler is working with a team from Germany and the USA to study Group 3 medulloblastoma. The team will be analysing the genome in medulloblastoma tumour cells while also working on new ways to test drugs for this tumour type.

If successful, the research could, for the first time, reveal how these tumours are wired. This could mean that new drugs to treat this tumour type are delivered to the clinic within five years.

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Prof. Colin Kennedy

Quality of survival in a Europe-wide clinical trial

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Professor Colin Kennedy

Quality of survival in a Europe-wide clinical trial

This funding supports the quality of survival aspects of the European clinical trial entitled SIOP-PNET5-MB. This trial is for children with medulloblastoma tumours that have been defined in the clinic as "standard risk". The purpose of the trial is to assess whether treatment can be reduced so that these children experience less long term side effects, but still benefit from the anti-tumour activity of the protocol.

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Mr Conor Mallucci

Solving the mystery behind Cerebellar Mutism Syndrome

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Mr Conor Mallucci

Solving the mystery behind Cerebellar Mutism Syndrome

Mr Mallucci will be carrying out a multi-centre study to investigate Cerebellar Mutism Syndrome (CMS), a.k.a. Posterior Fossa Syndrome, a serious and poorly understood late effect resulting from surgical complication. It is seen in up to 25% of children after removing tumours from the very back of the skull, known as the cerebellum.

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Current low grade brain tumour research projects

Here are the research projects we are currently funding that relate to understanding or treating low grade brain tumours in children

Prof. Colin Watts

Tessa Jowell BRAIN MATRIX

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Professor Colin Watts

Tessa Jowell BRAIN MATRIX

The Tessa Jowell BRAIN-MATRIX is a first-of-its-kind clinical trial that will enable doctors to treat brain tumours with drugs that are more targeted than ever before. We are excited to be investing £2.8 million to set the trial up, and to drive it into the future.

Although the trial is being led from the UK, we expect it to deliver global impact for brain cancer patients.

Find out more

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Prof. Colin Kennedy

The PROMOTE Study

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Professor Colin Kennedy

The PROMOTE Study

The project is named The PROMOTE Study - Patient Reported Outcome Measures Online To Enhance Communication and Quality of Life after childhood brain tumour.

The PROMOTE team are developing an online programme called KLIK which will be used by children and their families to keep track of any issues they have between consultations.

This research will propel our ability to understand, and potentially prevent, the harsh side effects of brain tumour treatment in children to help accelerate a change for those affected.

Find out more

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Dr David Jones

The Everest Centre

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Dr David Jones

The Everest Centre

The Everest Centre is being financed by The Brain Tumour Charity with money raised by the family and friends of Toby Ritchie, who was diagnosed with a low grade brain tumour at the age of five. 

The centre will fund several, vital research projects that will help us understand more about low grade paediatric brain tumours and trial new treatments.

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Prof. Denise Sheer & Prof. JP Martinez-Barbera

Making models of paediatric low grade glioma

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Professor Denise Sheer & Professor JP Martinez-Barbera

Making models of paediatric low grade glioma

The team are working to create pre-clinical models for childhood low grade brain tumours (glioma).

Pre-clinical models are used by scientists to test new treatments in the lab before they are then used in humans, as part of a clinical trial.

Once we know the models work correctly, we can understand how the tumour can be treated and defeated. Low grade gliomas currently account for half of children with brain tumours, so this will be a significant advance.

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Dr Susan Picton

Testing a new drug combination for young people with low grade brain tumours

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Dr Susan Picton

Testing a new drug combination for young people with low grade brain tumours

Dr Susan Picton and colleagues at the University of Leeds and Birmingham Clinical Trials Unit are conducting a clinical trial to determine the potential value and best dose when combining the drugs nilotinib and vinblastine to treat young people with brain tumours.

The researchers are focusing on low grade childhood brain tumours called gliomas. Gliomas are often inoperable because of their location and can become more aggressive over time.

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Dr Todd Hankinson

Identifying directed therapies for Adamantinomatous Craniopharyngioma (ACP)

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Dr Todd Hankinson

Identifying directed therapies for Adamantinomatous Craniopharyngioma (ACP)

Almost all children with ACP suffer from a life-altering side effect or injury from either the tumour itself or treatment. Side effects and injuries include hormone imbalances, blindness, and morbid obesity. The current standard of treatment includes surgical removal of the tumour followed by radiation therapy – there are currently no targeted therapies to treat ACP.

The aim of the research programme, led by Dr Todd Hankinson, is to understand the behaviour of the different types of cells and identify targets for treatment.

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Dr Ruman Rahman

'Shining light' on childhood brain tumours to reveal new therapy targets

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Dr Ruman Rahman

'Shining light' on childhood brain tumours to reveal new therapy targets

Identifying unique alterations in the genetic make-up of ependymoma is beginning to provide clues for new targeted treatments. One such key alteration is a mutation called C11orf95-RELA, which is formed as two genes fuses together.

Dr Rahman at The University of Nottingham will use a powerful gene editing tool to allow his team to control the genetic pathways involved in the fusion of C11orf95-RELA.

Find out more

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